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KMID : 0665420220370050438
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Korean Journal of Food Culture
2022 Volume.37 No. 5 p.438 ~ p.445
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Antioxidant and Immunomodulatory Effects of Laminaria japonica Water Extract
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Cui Jiamei
Kim Eun-Young
Zhang Guiguo
Lee Yun-Kyoung
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Abstract
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Laminaria japonica is a type of brown algae widely consumed in Asian countries and contains many essential nutrientsand exhibits anti-obesity, antioxidant, and anti-inflammatory effects. In this study, the antioxidant and immunomodulatoryeffects of a Laminaria japonica water extract (LJE) were investigated using an in vitro model. Mean total polyphenol contentof LJE was 2.16±0.11 μg GAE/mg, and LJE dose-dependently inhibited ABTS radical activity but did not scavenge DPPHradicals. In addition, LJE enhanced nitric oxide (NO) production and upregulated the mRNA expressions ofproinflammatory cytokines (i.e., tumor necrosis factor-α and interleukin-6) in RAW 264.7 cells. On the other hand, LJEinhibited NO production and downregulated proinflammatory cytokine mRNA levels in endotoxin-stimulated RAW 264.7cells. Thus, our data show that LJE has moderate antioxidant activity and biphasic immunomodulatory effects on RAW264.7 cells. In summary, the study indicates that LJE has potential therapeutic use as a novel biphasic immuno-modulator.
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KEYWORD
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Laminaria japonica, extract, antioxidant, immunomodulatory, anti-inflammatory effect
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